metribolone

The therapeutic concentration is maintained. to plasma proteins – 10-15%. . The volume of distribution – 0.26 l / kg is distributed relatively evenly in various tissues and body fluids: lungs, liver, heart, kidneys, gall, gall bladder, bones, joints, respiratory tract. Poor permeates through unmodified blood-brain barrier metribolone. Passes through the placenta, in a small amount is excreted in breast milk and is found in amniotic fluid. Do not metabolized.In violation of renal excretory function in the blood concentration increases and the launch time is extended by the kidneys, after ingestion -. 5-30 hours Moderate displayed by hemodialysis, well – using peritoneal dialysis.

 

Indications
The infectious-inflammatory diseases caused by microorganisms sensitive to cephalexin:
Infections of the upper and lower respiratory tract infections (bronchitis, pneumonia, bronchopneumonia, empyema and lung abscess); metribolone tract (pharyngitis, otitis media, sinusitis, tonsillitis); urogenital system (pyelonephritis, cystitis, urethritis, prostatitis, epididymitis, endometritis, gonorrhea, vulvovaginitis); skin and soft tissue (furunculosis, abscess, cellulitis, pyoderma, lymphadenitis, lymphangitis);bone and joints (including osteomyelitis).

Contraindications:
Hypersensitivity (including to other beta-lactam antibiotics.), Children up to 10 years (for a given dosage form). Be wary – kidney failure, pseudomembranous colitis (in history), pregnancy, lactation.

Pregnancy and lactation
Use of the drug during pregnancy and lactation is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary, the appointment during lactation should stop breastfeeding.

Dosing and Administration
Inside for 30-60 minutes before meals with water.
The average dose for adults and children older than 10 years -. 250-500 mg every 6 hours daily dose should be at least 1-2 g, if necessary may be increased to 4, the duration of treatment – 7-14 days. In infections caused by beta-hemolytic streptococcus group A, the minimum duration of treatment is 10 days.
Adult patients with impaired renal function, the daily dose should be reduced, taking into account the values of creatinine clearance metribolone in spacecraft 5-20 ml / min, the maximum daily dose – 1 5 g / day; QC at least 5 ml / min – 0.5 g / day. The daily dose is divided into 2-4 reception.

Children under the age of 10 are encouraged to nominate a preparation in the form of a suspension for oral administration. When body weight less than 40 kg average daily dose – 25-100 mg / kg body weight;the multiplicity of reception – 4 times a day. With otitis media – a dose of 75 mg / kg / day, the multiplicity of reception – 4 times a day. When streptococcal pharyngitis, skin infections and soft tissues of the multiplicity of reception – 2 times a day. In severe infections the daily dose can be increased to 100 mg / kg body weight, and the multiplicity of reception – up to 6 times per day.

Side effects
: Allergic reactions: rash, urticaria, angioedema, erythema, rarely – eosinophilia, toxic epidermal necrolysis, Stevens-Johnson syndrome, anaphylactic shock.
From the digestive system: abdominal pain, dry mouth, anorexia, nausea, vomiting, diarrhea, gastritis, chronic hepatitis, cholestatic jaundice, increased activity of “liver” transaminases and alkaline phosphatase, increase in bilirubin, candidiasis of the intestine, mouth, pseudomembranous colitis.
From the nervous system: dizziness, weakness, headache, agitation, hallucinations, convulsions .
from the urogenital metribolone system: interstitial nephritis, itchy genitals and anus, vaginitis, vaginal candidiasis genitals.
from the side of hematopoiesis: leukopenia, neutropenia, thrombocytopenia, pancytopenia, agranulocytosis, aplastic anemia, hemolytic anemia.
from the musculoskeletal -dvigatelnogo system: arthralgia, arthritis.
Laboratory indicators: increase in prothrombin time.
Other: fever.