The use of the drug during pregnancy is possible only when the metribolone results of primary intended benefits to the mother outweighs the potential risk to the fetus. Cefotaxime is excreted in breast milk, so breast-feeding should be discontinued, if necessary, the appointment during lactation.
Dosage and administration
Adults and children over 12 years: in uncomplicated infections, as well as urinary tract infections – a / m or / in 1 g every 8 – 12 hours; with uncomplicated acute gonorrhea -1 g / m once; at moderate infections – a / m or / in the 1-2 g every 12 hours; in severe infections, such as meningitis -in / in 2 g every 4-8 hours, maximum daily dose – ’12
Duration of treatment is determined individually.
In order to prevent the development of infections before surgery is administered during induction of general anesthesia, the single 1 If necessary, repeat administration of 6-12 hours.
When cesarean section – at the time clips overlay umbilical vein – in / 1 g, and then at 6 and 12 hours after the first dose – in addition to 1 g
In the case of renal function reduce the dose. If creatinine clearance of 20 mL / min / 1.73 m and less than the daily dose reduced by metribolone results of primary 2 times.
Children under the age of 2.5 years, intramuscular administration of the drug is contraindicated.
Terms of preparing and administering injections.
For intramuscular injection, the drug is dissolved in 0.5 g of 2 ml (or 1 g in 4 ml) of sterile water for injection, injected deep into the gluteal muscle. As the solvent, when administered intramuscularly also used 1% lidocaine solution (0.5 g – 2 mL per 1 g – 4 mL).
For intravenous administration of 0.5 – 1 g product is dissolved in 10 ml of sterile water for injection. Enter slowly for 3-5 minutes.
For drip (for 50-60 minutes) is dissolved 2 g in 100 ml of isotonic sodium chloride solution or 5% glucose solution.
Side effects: Allergic reactions: urticaria, chills or fever, rash, pruritus, rarely -bronhospazm, eosinophilia, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), angioedema, anaphylactic shock.
From the gastrointestinal tract: nausea, vomiting, diarrhea or constipation, bloating, abdominal pain, goiter, liver dysfunction, rarely – stomatitis, glossitis, pseudomembranous enterocolitis.
Since the cardiovascular system: a potentially life-threatening arrhythmias after a rapid bolus into the central vein.
From the side of hematopoiesis: leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia, anticoagulation.
From the urinary system: renal dysfunction metribolone results of primary (oliguria, anuria).
From the nervous system: headache, dizziness.