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Metribolone

metribolone steroid side

Medication has analgesic, antipyretic and anti-inflammatory effect. Naproxen are metribolone steroid side, the mechanism of action of which is associated with the inhibition of prostaglandin synthesis and effects on the thermoregulatory center in the hypothalamus. Caffeine has a psychostimulant, analeptic and antispasmodic effect on smooth muscle, it stimulates the striated muscles, reduces platelet aggregation and release of histamine from mast cells.

Indications for use
– as an analgesic for pain syndrome mild to moderate severity: neuralgia, myalgia, sciatica, lumbago; degenerative-dystrophic diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, ankylosing spondylitis), headache, toothache, migraine; Primary tuberculosis,
– as an antipyretic: feverish syndrome with colds, infectious diseases, inflammatory diseases.

 

Contraindications

Hypersensitivity to the drug, gastric ulcer and duodenal ulcers (acute phase), anticoagulation, severe renal and / or hepatic insufficiency, hypertension, organic diseases of the cardiovascular system, heart failure, anxiety, insomnia, angle-closure glaucoma, bronchial obstruction (in including those caused by non-steroidal anti-inflammatory drugs), the elderly and metribolone steroid side children (under 16 years), age, pregnancy, lactation.

Dosing and Administration

Rectal. Suppository free from blisters and after spontaneous bowel cleansing enema or enter deeply into the rectum 1 suppository 1-3 times a day. After the introduction of the suppository is necessary to stay in a horizontal position for 30-40 minutes.

The duration of intake without consulting your doctor no more than 5 days in the appointment as an analgesic and 3 days as antipyretic.

Side effect

Allergic reactions, dizziness, agitation, sleepiness, slowing of psychomotor reactions, tinnitus, tachycardia, increased blood pressure, thrombocytopenia, agranulocytosis, aplastic anemia, liver and / or kidney problems; itching and pain in the rectum.

Interaction with other drugs

Tsefekon H reduces the antihypertensive effect of beta-blockers,  inhibitors; It enhances the effect of anticoagulants, oral hypoglycemic agents – sulfonylurea derivatives.

special instructions

When the itching or discomfort in the rectum must be rectally introduce 15 ml of sunflower oil (1 tablespoon) and temporarily stop using the product.

release Form

Metribolone steroid side suppositories. 5 suppositories in blisters; Two blisters with instruction on medical use of the drug in a carton box.

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Local reactions: phlebitis, pain along the vein, pain and infiltration in the ground / m introduction.

Laboratory indicators: increased activity of “liver” transaminases, alkaline phosphatase, hypercreatininemia, hyperbilirubinemia, azotemia, increased urea in the blood, a positive Coombs’ test.

Other: superinfection (including candidiasis metribolone vs trenbolone for sale vaginitis).

Overdose symptoms: seizures, encephalopathy (in the case of high doses, especially in patients with renal insufficiency), tremor, increased neuromuscular excitability. Treatment: symptomatic therapy.

Interaction with other drugs
increases the risk of bleeding when combined with antiplatelet agents, and nonsteroidal anti-inflammatory drugs.

With simultaneous use of cefotaxime with potentially nephrotoxic drugs (aminoglycosides, polymyxin B, “loop” diuretics) need to monitor renal function (risk of nephrotoxicity of the latter).

Drugs that block tubular secretion, increase the concentration of cefotaxime in plasma and slow down its elimination.

cefotaxime solution is pharmaceutically incompatible with solutions of other antibiotics in the same syringe or dropper.

Cautions
In the first weeks of treatment may be metribolone vs trenbolone for sale pseudomembranous colitis manifested by severe prolonged diarrhea. In this case stop taking the drug and prescribe appropriate therapy, including vancomycin or metronidazole.

Before the appointment of the drug should be collected allergic history, especially with regard to beta-lactam antibiotics. Known cross-allergy between penicillins and cephalosporins. In the event of hypersensitivity reactions (which are severe and even lead to death) drug overturned.

When the duration of drug treatment over 10 days need to be monitored picture peripheral blood.

When determining glucose in urine nonenzymatic method (for example, by Benedict) false-positive results are possible.

During treatment, you can not use ethanol – possible effects, similar to the action of disulfiram (facial flushing, abdominal cramps and metribolone vs trenbolone for sale in the stomach, nausea, vomiting, headache, decreased blood pressure, tachycardia, shortness of breath).

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metribolone results of primary

The use of the drug during pregnancy is possible only when the metribolone results of primary intended benefits to the mother outweighs the potential risk to the fetus. Cefotaxime is excreted in breast milk, so breast-feeding should be discontinued, if necessary, the appointment during lactation.

Dosage and administration
Adults and children over 12 years: in uncomplicated infections, as well as urinary tract infections – a / m or / in 1 g every 8 – 12 hours; with uncomplicated acute gonorrhea -1 g / m once; at moderate infections – a / m or / in the 1-2 g every 12 hours; in severe infections, such as meningitis -in / in 2 g every 4-8 hours, maximum daily dose – ’12

Duration of treatment is determined individually.

In order to prevent the development of infections before surgery is administered during induction of general anesthesia, the single 1 If necessary, repeat administration of 6-12 hours.

When cesarean section – at the time clips overlay umbilical vein – in / 1 g, and then at 6 and 12 hours after the first dose – in addition to 1 g

In the case of renal function reduce the dose. If creatinine clearance of 20 mL / min / 1.73 m and less than the daily dose reduced by metribolone results of primary 2 times.

Children under the age of 2.5 years, intramuscular administration of the drug is contraindicated.

Terms of preparing and administering injections.
For intramuscular injection, the drug is dissolved in 0.5 g of 2 ml (or 1 g in 4 ml) of sterile water for injection, injected deep into the gluteal muscle. As the solvent, when administered intramuscularly also used 1% lidocaine solution (0.5 g – 2 mL per 1 g – 4 mL).

For intravenous administration of 0.5 – 1 g product is dissolved in 10 ml of sterile water for injection. Enter slowly for 3-5 minutes.

For drip (for 50-60 minutes) is dissolved 2 g in 100 ml of isotonic sodium chloride solution or 5% glucose solution.

Side effects: Allergic reactions: urticaria, chills or fever, rash, pruritus, rarely -bronhospazm, eosinophilia, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell’s syndrome), angioedema, anaphylactic shock.

From the gastrointestinal tract: nausea, vomiting, diarrhea or constipation, bloating, abdominal pain, goiter, liver dysfunction, rarely – stomatitis, glossitis, pseudomembranous enterocolitis.

Since the cardiovascular system: a potentially life-threatening arrhythmias after a rapid bolus into the central vein.

From the side of hematopoiesis: leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia, anticoagulation.

From the urinary system: renal dysfunction metribolone results of primary (oliguria, anuria).

From the nervous system: headache, dizziness.

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metribolone vs halotestin pre

Cefotaxime is a cephalosporin antibiotic III generation for parenteral administration. Effective bactericidal, disrupting the synthesis of cell walls of microorganisms. It has a wide spectrum of antimicrobial action.

It is active against   metribolone vs halotestin pre bacteria that are resistant to other antibiotics: Staphylococcus spp. (Including Staphylococcus aureus, including penicillinase forming strains), Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Enterococcus species, Enterobacter spp., Escherichia coli, Haemophilus influenzae (including strains forming penicillinase) , Haemophilus parainfluenzae, Klebssiella spp. (Including Klebssiella pneumoniae), Morganella morganii, Neisseria gonorrhoeae (including strains forming penicillinase), Acinetobacter species, Corynebacterium diphtheriae, Erysipelothrix insidiosa, Eubacterium spp., Propionibacterium spp., Bacillus subtilis, Clostridium spp. (Including Clostridium perfringens), Citrobacter spp., Proteus mirabilis, Proteus indole, Proteus vulgaris, Providencia spp. (Including Providencia rettgeri), Serratia spp., Pseudomonas aeruginosa, Neisseria meningitidis, Bacteroides spp. (Including some strains of Bacteroides fragilis), Fusobacterium spp. (Including Fusobacterium nucleatum), Peptococcus spp., Peptostreptococcus spp.

Most strains of Clostridium difficile – resistant.

Cefotaxime resistant to most beta-lactamases and metribolone vs halotestin pre negative microorganisms.

Pharmacokinetics
after single intravenous  administration at doses of 0.5; 1.0 g and 2.0 the maximum concentration is achieved after 5 min and at 39 g / ml, 101.7 pg / ml and 214 ug / ml, respectively. Following intramuscular (i / m) administration at doses of 0.5; 1.0 the maximum concentration is reached after 0.5 hours, and at 11 and 21 ug / ml, respectively. Relationship to plasma proteins – 30-50%. Bioavailability – 90 – 95%.

Creates therapeutic concentrations in most tissues (myocardium, bone, gall bladder, skin, soft tissue) and fluid (synovial, pericardial, pleural, phlegm, bile, urine, cerebrospinal fluid) of an organism. The volume of distribution – 0.25 – 0.39 L / kg. The half – 1 hour at / in the introduction and 1-1.5 hours -at the / m introduction.

Excreted by the kidneys – 20 – 36% in an unmodified form, the rest – in the form of metabolites (15 – 25% – in the form of a pharmacologically active dezatsetiltsefotaksima and 20 – 25% – as inactive metabolites – M2 and MOH).

In chronic renal failure and in the elderly half-life increased by 2 times. The half-life in newborns -0,75-1,5 hours; in preterm newborn infants (weight less than 1500 g) increases to 4.6 hours in children weighing more than 1500 g – 3.4 hours after metribolone vs halotestin pre repeated on / in a dose of 1 g every 6 hours for 14 days cumulation. not visible. Penetrates into breast milk.

Indications
Bacterial infection heavy currents, caused by susceptible microorganisms: central nervous system infections (meningitis), lower respiratory , urinary tract, bones, joints, skin and soft tissues of the pelvic organs, infected wounds and burns, peritonitis , septicemia, abdominal infections, endocarditis, Lyme disease (borreliosis), salmonellosis, infections due to immune deficiency, prevention of infections after surgery (including urology, obstetrics and gynecology, gastro-intestinal tract), gonorrhea.

Contraindications
Hypersensitivity to cephalosporin antibiotics metribolone vs halotestin pre (including penicillins, cephalosporins other, carbapenems); children up to 2.5 years of intramuscular administration of the drug.

Precautions: in the neonatal period; during pregnancy and lactation; patients with impaired renal and hepatic function; in ulcerative colitis (including history).

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metribolone dosage

Aminoglycosides, “loop” diuretics, drugs that reduce tubular secretion, increase nephrotoxicity.
Incompatible with ethanol (inhibits atsetaldegidrogenazu) develop disulfiramopodobnye reactions (abdominal pain, facial flushing, headache, decreased blood pressure, nausea, vomiting, palpitations, sweating).
The solution is pharmaceutically incompatible with metribolone dosage aminoglycosides.

Cautions
Patients who had a history of allergic reaction to penicillin, may be sensitive to cephalosporin antibiotics.
During treatment with cefamandole possible: false-positive direct Coombs’ test, false positive reaction of urine for glucose, proteinuria.
In elderly and debilitated patients with a deficiency  there is an increased the risk of hypoprothrombinemia with or without bleeding (in these cases shows the introduction of vitamin K).
During treatment should refrain from receiving ethanol – possible effects, similar to the action of disulfiram (facial flushing, abdominal cramps and in the stomach, nausea, vomiting, . headache, decrease blood pressure, tachycardia, dyspnea)
a freshly prepared solution unfit for use within 24 hours when stored at room temperature and for 96 hours – when stored in the refrigerator.

Release form
of 0.5 g and 1.0 g of the active metribolone dosage substance in glass bottles with a capacity of 10 ml.
In 1 or 5 vials in a cardboard box with the instructions for medical use.
In 1 or 5 vials in blisters together with the solvent ( water for injections). Every contour packing in a cardboard box with the instructions for medical use.
1 bottle together with the solvent in a stack of cardboard packaging without contour. In one pack put the instructions for use.
On 50 vials are placed in a cardboard box with a 1-5 instructions for use metribolone dosage (for hospitals).